Ecology and Evolution of Infectious Diseases
Dispersal of Mycobacterium tuberculosis via the Canadian fur trade. Pepperell CS, Granka JM, Alexander DC, Behr MA, Chui L, Gordon J, Guthrie JL, Jamieson FB, Langlois-Klassen D, Long R, Nguyen D, Wobeser W, Feldman MW. Proc Natl Acad Sci U S A. 2011 Apr 19;108(16):6526-31.
These are some of the questions we are interested in. Work in the lab centers on analysis of genomic data sets from natural populations of humans and human pathogens. For the most part we focus on granulomatous diseases (e.g. TB, invasive fungal infections) that result from complex and sustained interactions between pathogen and host, and are associated with diverse outcomes. We use a variety of different data types (e.g. epidemiological, historical, ethnographic, archeological) to contextualize analyses of population genetic data. We also work with collaborators to develop ecological models and address these questions using integrated ecological and evolutionary approaches.